We had a nice slate of games last week to tease us for the true start to the college football season! The ACC and Big 12 kick off this weekend, including six of our ranked schools going at it, headlined by two in-conference games: Syracuse at North Carolina and Duke at Notre Dame. Of course, the start of the college football season brings some of the best betting action of the year, and we’ve been waiting a long time for it, so let’s go with my five top bets of the Week Two action in College Football.

Syracuse (+23) at North Carolina
The Tar Heels and Mack Brown start their season with a lot of hope at an ACC Title, but they will need to brush off the rust against a decent Syracuse squad. While UNC should win this game, having to win by more than three touchdowns is a huge ask.

Duke (+21.5) at Notre Dame
Another game with a lot on the line is this opening in the ACC for the Irish. If they want any chance at going against Clemson for the crown, they will need to start with a win over the Blue Devils. Again, three touchdowns is a lofty ask, especially considering the last time Duke traveled to South Bend, they came away with the upset. The Blue Devils should be improved over last year’s team, with former Clemson backup Chase Brice leading the offense.

South Alabama (+10) v Tulane
The Jaguars just got their first road win since 2017 and now have their inaugural game at Hancock Whitney Stadium. Going against this Tulane team won’t be an easy ask, but South Alabama has a lot of talent at receiver and a game under their belt. Should be a close one!

Western Kentucky at Louisville (Over 57.0)
In Year Two of Scott Satterfield at Louisville, the Cardinals should be all gears ready for a great ACC campaign. But first they face in-state foe Western Kentucky, who they beat 38-21 last year at Nissan Stadium in Nashville. They were rolling much of the year and should be all cylinders go here. But they won’t get an easy game, with a touch Hilltoppers squad looking to score some points here too – should be a shootout!

Kansas (-6.5) v Coastal Carolina
The Jayhawks have revenge on their mind when the Chanticleers come to town. Just last year, Lawrence, Kansas saw the Jayhawks stunned by Coastal Carolina 12-7. Now it is Round Two and I know these Kansas players don’t want to go down again like that. Year Two under Les Miles should see this team be very improved and coast with a win by at least a touchdown, if not more.

All lines compliments of DraftKings Sportsbook.